Physical and Pharmacological Consequences of Cannabis

Introduction:<br />Hashish [http://justinroom.com/profile_info.php?ID=412266 get the best marijuana vaporizer online]   is just not only the most abused illicit drug within the Usa (Gold, Frost-Pineda, & Jacobs, 2004; NIDA, 2010) it is in fact by far the most abused illegal drug worldwide (UNODC, 2010). While in the U.s. it is a schedule-I substance which means that it is legally considered as having no medical use and it is highly addictive (US DEA, 2010). Doweiko (2009) explains that not all hashish has abuse potential. He therefore suggests using the common terminology cannabis when referring to cannabis with abuse potential. For the sake of clarity this terminology is used in this paper as well.<br /><br />Today, cannabis is at the forefront of international controversy debating the appropriateness of its widespread illegal status. In many Union states it has become legalized for medical purposes. This trend is known as "medical marijuana" and is strongly applauded by advocates while simultaneously loathed harshly by opponents (Dubner, 2007; Nakay, 2007; Van Tuyl, 2007). It is in this context that it was decided to choose the topic of the bodily and pharmacological consequences of marijuana for the basis of this research article.<br /><br />What is marijuana?<br />Cannabis is a plant more correctly called cannabis sativa. As mentioned, some hashish sativa plants do not have abuse potential and are called hemp. Hemp is used widely for various fiber products including newspaper and artist's canvas. Cannabis sativa with abuse potential is what we call marijuana (Doweiko, 2009). It is interesting to note that although widely studies for many years, there is a lot that researchers still do not know about marijuana. Neuroscientists and biologists know what the effects of cannabis are but they still do not fully understand why (Hazelden, 2005).<br /><br />Deweiko (2009), Gold, Frost-Pineda, & Jacobs (2004) point out that of approximately four hundred known chemicals found in the hashish plants, researchers know of over sixty that are thought to have psychoactive effects on the human brain. By far the most well known and potent of these is â??-9-tetrahydrocannabinol, or THC. Like Hazelden (2005), Deweiko states that while we know many of the neurophysical results of THC, the reasons THC produces these effects are unclear.<br /><br />Neurobiology:<br />As a psychoactive substance, THC directly affects the central nervous system (CNS). It affects a massive range of neurotransmitters and catalyzes other biochemical and enzymatic activity as well. The CNS is stimulated when the THC activates specific neuroreceptors during the brain causing the various actual physical and emotional reactions that will be expounded on more specifically further on. The only substances that can activate neurotransmitters are substances that mimic chemicals that the brain produces naturally. The fact that THC stimulates brain function teaches scientists that the brain has natural cannabinoid receptors. It is still unclear why humans have natural cannabinoid receptors and how they work (Hazelden, 2005; Martin, 2004). What we do know is that marijuana will stimulate cannabinoid receptors up to twenty times more actively than any of the body's natural neurotransmitters ever could (Doweiko, 2009).<br /><br />Perhaps the biggest mystery of all is the relationship between THC and the neurotransmitter serotonin. Serotonin receptors are among by far the most stimulated by all psychoactive drugs, but most specifically alcohol and nicotine. Independent of marijuana's relationship with the chemical, serotonin is already a little understood neurochemical and its supposed neuroscientific roles of functioning and purpose are still mostly hypothetical (Schuckit & Tapert, 2004). What neuroscientists have found definitively is that marijuana smokers have very high levels of serotonin activity (Hazelden, 2005). I would hypothesize that it may be this relationship between THC and serotonin that explains the "marijuana maintenance program" of achieving abstinence from alcohol and allows cannabis smokers to avoid painful withdrawal symptoms and avoid cravings from alcohol. The efficacy of "marijuana maintenance" for aiding alcohol abstinence will not be scientific but is a phenomenon I have personally witnessed with numerous clients.<br /><br />Interestingly, marijuana mimics so many neurological reactions of other drugs that it is extremely difficult to classify in a specific class. Researchers will place it in any of these categories: psychedelic; hallucinogen; or serotonin inhibitor. It has properties that mimic similar chemical responses as opioids. Other chemical responses mimic stimulants (Ashton, 2001; Gold, Frost-Pineda, & Jacobs, 2004). Hazelden (2005) classifies marijuana in its own special class - cannabinoids. The reason for this confusion is the complexity of the numerous psychoactive properties found within marijuana, both known and unknown. One recent client I saw could not recover from the visual distortions he suffered as a result of pervasive psychedelic use as long as he was still smoking cannabis. This seemed to be as a result of the psychedelic properties found within active cannabis (Ashton, 2001). Although not strong enough to produce these visual distortions on its own, cannabis was strong enough to prevent the brain from healing and recovering.