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The principle of Clean space style begins from pretty much 150 years ago when these units were employed for bacterial handle in hospitals. Currently, clean rooms have completed a long way and developed for the modern technology. In earlier day, these clean rooms were made for fulfilling the requirement of clean atmosphere for industrial manufacturing through 1950s along with the same clean rooms are also used for assortment of applications in numerous industries.

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In 2003, Eli Lilly pioneered the development of a new method for the prevention and containment of cross contamination during the manufacture of pharmaceutical powders using a specially developed fog cart. This makes it possible for the operator to be covered by an exceptionally fine fog of water on exit from a important area, virtually eliminating the threat of transferring dust traces beyond their right confines.

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The concept of laminar flow was introduced through 1950s and 1960s, when NASAs space travel plan was initiated. This marked a turning point in clean area technology and from this time, the evolution of clean rooms gained momentum.

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